MANINIL 3
Pire | 1 ripa. |
micronized glibenclamide | 1.75 mg |
toa monotehe lactose, māka rīwai, methylhydroxyethyl cellulose, colloidal silikonida hauhā, konupora stearate, cochineal whero A (tae rai E124) |
i roto i nga ipu karaihe 120 piripiri., kei roto i te kete pepa 1 ipu, ki te kete blister ranei 10, 20 pcs ranei, i roto i te kete kareti 3 blisters.
Pire | 1 ripa. |
micronized glibenclamide | 3,5 mg |
toa monotehe lactose, māka rīwai, methylhydroxyethyl cellulose, colloidal silikonida hauhā, konupora stearate, cochineal whero A (tae rai E124) |
i roto i nga ipu karaihe 120 piripiri., kei roto i te kete pepa 1 ipu, ki te kete blister ranei 10, 20 pcs ranei, i roto i te kete kareti 3 blisters.
Pire | 1 ripa. |
glibenclamide | 5 mg |
toa te waipiro lactose, te konupora konupora, te māngaro rīwai, te talc, te gelatin, te whero a A (waikano E124) |
i roto i nga ipu karaihe 120 piripiri., kei roto i te kete pepa 1 ipu, i roto i te kete blister 20 pcs ranei, i roto i te kete pepa 1, 2, 3, 4, 6 ranei i te pupuhi.
Takaroa
I muri i te whakaurutanga o Maninil 3.5, ka kitea te whakauru ohorere me te tino kiki mai i te paparanga gastrointestinal. Ka whakaputahia katoa o te kaha kaha o te microionized i roto i te 5 meneti.
Ko te taangai o te pūmua Plasma he nui ake i te 98% mo Maninyl 3,5, 95%.
Ka tino whakaekehia o te ate ki te kopae e rua nga whakakino o te rongoa, tetahi o nga ngako, me tetahi atu ma te papa.
T1 / 2 mo Maninyl 3.5 he 1.5-3.5 haora.
Tikanga tono
Maninil 3.5 tangohia-ā-waha, te ata me te ahiahi, i mua i nga kai, me te korekore. Ka whakaritea te horopeta takitahi, i runga i te pakeke o te mate.
Ko te horopeta tuatahi ko te 1 / 2-1 papa, te toharite 1 te papa. ia ra, teitei - 3, i etahi atu keehi - 4 nga papa. ia rā.
Puka ia ra ki te 2 papa. te nuinga o te waa kotahi (i te ata), teitei ake - ka wehea kia 2 inenga (te ata me te ahiahi).
Nga mate taha
Ka taea te mate hypoglycemia (me te tohi haere i te kai, he overdose o te tarukino, me te whakapiki ake i te tinana, me te inu waipiro nui).
Mai i te taarua o te ngata tuuwha: i etahi wa - ka raru, ka ruaki, kei etahi keehi - jaundice cholestatic, hepatitis.
Mai i te punaha hemopoietic: he uaua rawa - thrombocytopenia, granulocytopenia, erythrocytopenia (tae atu ki te pancytopenia), i etahi waahanga - anemia hemolytic.
Tauhohenga mate pāhono: tino onge - rapa kiri, kirika, mamae tahi, proteinuria.
Tahi atu: i te tiimatanga o te maimoatanga, ka taea te mate uruta mai i nga wa katoa. I nga keehi onge, ko te whakaahuru.
Nga Panui
Kei te whakamahi i te tarukino Maninil 3.5 ko: hypersensitivity (tae atu ki nga raau taero sulfonamide me etahi atu derivatives sulfonylurea), momo 1 mate mellitus mate (insulin-whakawhirinaki), decompensation metabolic (ketoacidosis, precoma, koma), te taatai i muri i te whakahekenga puhipuhi, nga pepeha kino me nga mate whatukuhu, etahi nga tikanga o te mate (hei tauira, te huringa o te warowaihā o te warowaihā i roto i nga mate hopuhopu, te weranga, te whara, i muri ranei i nga rongoa nui ka tohua te haumanutanga o te insulin), leukopenia, te aukati i nga ngutu, takirua h puku, nga tikanga e haere tahi ana me te aukati o te kai me te whakawhanaketanga o te hypoglycemia, te hapu me te wa whakatinanatanga.
Te taunekeneke me etahi atu raau taero
Te whakapakari i te hua hypoglycemic o te tarukino Maninil 3.5 ka taea ki te whakamahi me te haukoti ACE, nga taakuta-anabolic me nga taiohi wahine tane, etahi taangata hypoglycemic oral (e.g., acarbose, biguanides) me te insulin, azapropazone, NSAID, beta-blockers, quinolone derivatives, chloramphenicol, clomofiber, disopyramide, fenfluramine, rongoā antifungal (miconazole, fluconazole), fluoxetine, MAO inhibitors, PASK, pentoxifylline (i te horopeta teitei mo te whakahaere matua te kai), perhexiline, derivatives pyrazolone, phosphamides (e.g. cyclophosphamide, ifosfamide, trophosphamide), probenecid, salicylates, sulfonamides, tetracyclines me tritoqualin.
Ko nga kaihoko waikawa urine (ammonium chloride, te konupūmā hauhi) e kaha ake ai te paanga o te tarukino Maninyl ma te whakaiti i te tohu o te wehewehe me te whakapiki i te reabsorption.
Ko te hua hypoglycemic a Maninil ka heke me te whakamahi i te barbiturates, isoniazid, diazoxide, GCS, glucagon, nicotinates (i roto i nga taangata tiketike), phenytoin, fenothiazines, rifampicin, thiazide diuretics, acetazolamide, hormones contraceptogen, estrogen hormones, estrogen estrogen, estrogen hormones, estrogen haukati o te ngongo konumohe puhoi, nga hinu lithium.
Ka taea e nga kaiwhakahauhau H2 taiharo te ngoikore, i tetahi taha, a, i runga i tetahi, whakakaha i te paanga hypoglycemic a Maninil.
I nga keehi koretake, ka taea e te pentamidine te paheketanga nui ranei te piki ake o te kukume o te toto toto.
Ki te whakamahi i te waipiro ki te raau taero, ka kaha ake ranei te Maninil ka whakarei ranei i te paanga o nga turunga Coumarin.
I te taha o te mahi hypoglycemic, beta-blockers, clonidine, guanethidine me reserpine, me nga raau taero me te tikanga whakahaere o te mahi, ka taea te ngoikore o nga tohu o te hypoglycemia.
Te paarua
Na te haeretanga o te hypoglycemia, ka ngaro pea te mana o te manawanui me te maaramatanga, te whanaketanga o te comog hypoglycemic.
Maimoatanga: i roto i te ngawari o te hypoglycemia, me tango e te manawanui tetahi waahanga o te huka, te kai me te inu ranei me te nui o te huka huka (miraka, honi, he karaihe paraihe karawhiwhi). I roto i te ngaro o te maarama, he mea tika ki te kuhu i te haurangi iv - 40-80 ml o te 40% otinga dextrose (kūmara), katahi ka haehae te 5-10% otinga dextrose. Na ka taea e koe te whakauru atu ki te 1 mg o te glucagon i roto i /,, m, s / c ranei. Ki te kore e mohio te manawanui, ka taea te whakahoki ano i tenei meera;
Puka puka
Maninil 3.5 - papa.
Kakano - ki nga ipu karaihe o te 120 pcs., I roto i te kete kaata i roto i te 30, 60 ranei ia.
1 papa Maninil 3.5 kei roto i nga mea kaha: glibenclamide (kei roto i te miihiniiti) 3.5 mg.
Nga Kaihautū: te waikawa lactose, te māngaro rīwai, te gimetellosa, te hakihaki korepu o te konupora, te kowhatu konupora, te waikano maramara (Ponceau 4R) (E124)
Te mahi rongoā
He mate pancreatic me te extrapancreatic. Ka whakaatuhia te mahi pancreatic i te whakaongaonga o te hanga insulin e nga pūtau beta pancreatic, a ko te mahi extrapancreatic e kitea ana ki te whakapiki ake i te taarongo o nga kaiwhakatakoto taiwhiwhi whaanui (e pa ana ki te whakaongaonga ngate tyrosine) ki te insulin, me te aukati o te gluconeogenesis me te glycogenolysis i te ate.
Haumanu Hauora
Ko te ahua Micronized e whakarato ana i te whakatutukitanga o mua o Cmax , ko te raupapatanga o te mate hypoglycemic e hono ana ki te tihi o te hyperglycemia postprandial, e whakarite ana i te paanga o te ahupūngao hei whakakotahi me te T1/2 ka whakaiti i te mate o te hypoglycemia. Ko te hiahia o ia ra mo te glibenclamide ka heke pea i te 30-40%.
Nga mahi whakaoranga haumaru
Ka whakamahia ma te tupato ki te take o te whakapae febrile, te mate mate thyroid (me te ngoikoretanga o te mahi), te hypofunction o te pituitary o mua, te cortex adrenal ranei, te waipiro, i nga taangata tuuturu na te kaha o te whakawhanake hypoglycemia. Kei te hiahiatia nga tirotiro hauora tonu. I te wa o te maimoatanga, me tino whai koe i tetahi kai. Ko te tango i a Maninil kaore e whakakapi i te kai. I te wa o te maimoatanga, kaore i te tūtohutia kia uru atu ki nga mahi e hiahia ana ki te aro nui me te tere o te urupare psychomotor, kia noho tonu mo te ra mo te wa roa. Ko te whakarerekētanga horopeta e tika ana kia nui rawa te taha tinana me te awangawanga, he rereke ki te kai.
Te inenga me te huarahi whakahaere o te tarukino.
Ka whakaritea te horopeta takitahi, i runga i te pakeke, te pakeke o te mate huka, te glycemia nohopuku me te 2 haora i muri o te kai.
Ko te horopeta toharite ko te 2.5-15 mg / ra, ko te maha o nga mana whakahaere ko te 1-3 wa / ra. Tangohia 20-30 meneti i mua i te kai. I roto i te horopeta neke atu i te 15 mg / ra, ka whakamahia ki nga keera kaore i te whai hua nui o te mate hypoglycemic.
Mo nga turoro tuunga, ko te horopeta tuatahi ko te 1 mg / ra.
I te huringa mai i biguanides, ko te horopeta tuatahi o te glibenclamide he 2.5 mg / ra. Ko te Biguanides me whakakorehia, me te horopeta o te glibenclamide, mehemea e tika ana, ka taea te piki ake i te 2,5 mg ia nga ra 5-6 hei utu mo nga takahi o te warowaihā. I te kore o nga utu mo te 4-6 wiki, he mea tika ki te whakamahere i nga maimoatanga me te glibenclamide me biguanides.
Nga paanga o Maninil 3.5:
Mai i te punaha endocrine: hypoglycemia tae atu ki te piko (ka piki ake te tupono o tana whanaketanga me te takahi o te tikanga whakakahango me te kai hika)
Hohenga tauhohenga: kiri kiri, kauhau.
Mai i te punaha o te tuunui: te nausea, te hakihaki, te ngakau pouri i te rohe epigastric, kaore i roa - he ngoikoretanga o te ate ate, cholestasis.
Mai i te taha o te punaha whakato nui, me te punaha-a-toto peka: he uaua - te paresis, te ngoikoretanga o te taikaha, te mamae, te ngoikore, te ngoikore, te ngoikoretanga.
Mai i te punaha hematopoietic: varavara - he mate mate hematopoiesis tae noa ki te whanaketanga o te pancytopenia.
Tauhohenga dermatological: varavara - photosensitivity.
He tohutohu motuhake mo te whakamahinga o Maninil 3.5.
Kei te whakamahia te whakatupato i roto i nga turoro me te pathology o te ate me nga whatukuhu (tae atu ki te hitori), me te kirika, te taumahatanga o te mahi adrenal, te mate thyroid, me te waipiro haurangi.
I roto i te rongoa, ko te aro turuki i te toto o te toto me te tangohanga huka toto korehau o ia ra.
Ma te whakawhanaketanga o te hypoglycemia, mena kei te mohio te manawanui, he mate ngako (he otinga huka ranei) kei roto. I roto i te take ka ngaro te maarama, ka whakahaerehia te haumanu o te kopu, te glucagon sc ranei, ka whakahaerehia a intramuscularly, intravenously ranei. I muri o te whakahoki mai i te mohio, he mea tika kia whakawhiwhia te kai a te tangata manawanui ki te warowaihā kia kore ai te whanaketanga o te hypoglycemia.
Ko te hunga mate e mau ana i te glibenclamide me karo ki te inu waipiro. I roto i te keehi o te waipiro, ka taea te whanaketanga o te tauhohenga disulfiram, me te hypoglycemia kino.
Whakawaenga o Maninil 3.5 me etahi atu raau taero.
Ko te whakapakari i te hua hypoglycemic o te glibenclamide ka taea me te whakamahi i te waa o te beta-blockers, nga kaihoko a-anabolic, allopurinol, cimetidine, clofibrate, cyclophosphamide, isobarin, MAO te maukati, roa te mahi, he miihopiri roa, kaimurahia, chloramphenicol, tetracycline, etane.
Ko te ngoikore o te mahi o te glibenclamide me te whanaketanga o te hyperglycemia ka taea i te wa ano te whakamahi i te barbiturates, chlorpromazine, fenothiazines, phenytoin, diazoxide, acetazolamide, glucocorticoids, sympathomimetics, glucagon, indomethacin, he nui o te wa o te nikotinate, te takawaenga o te waikawa, te waihoki, te waikawa o te waikawa, te kowhiri, te waikawa, te waikawa, te waihonga, te waikawa, te waatea potahe teitei o laxatives.