Te tūranga koiora o te cholesterol

Ko te Cholesterol tetahi waipiro whakahekenga monoatomic, ka ngawari te hanga cholesterides i roto i te kopa. Ka uru ki roto i te tinana o te tangata hei waahanga o te kai ka kuhu ki te ate, te whekau iti me te kiri.

Te tūranga koiora o te cholesterol:

1. Te hanganga. Ko te korikori Koreutu he waahanga hanganga o nga membrane pūtau.

2. Ko te Hakihaki. Ko te Cholesterol he kaupapa nui ki nga matū kaha o te koiora: huaora D3, HAKANGA STEROID (ANDROGENS, ESTROGENS, CORTICOIDS) I te wa o te kaha o te hāora i roto i te ate me te whakauru o CYTOCHROME R-450, ka hangaia nga waikawa roro. I roto i ona momo koreutu, ka whakahaerehia te cholesterol ma te tinana ma te whakamahi i te toto kawe LIPOPROTEINS. Nga puna o te cholesterol:

1. Kai. Mo te ra, 0.3 g. cholesterol.

2. I te taangata, i te toharite, me te nui o te 65-70 kg ia ra, ko te 3.5 -4.2 g te kotahitanga. cholesterol. Ko te ate e noho ana ki te waahi nui o te hakihaki o te cholesterol.Ko te kino o te ate me nga whekau, ka pakaru te ahua me te kawenga o te toto toto. Na te kino o te ate me te taarua o te taikaha, ka pakaru te whakaputanga me te tangohanga o nga waikawa raupatu e whai wāhi atu ana ki te keri o nga ngako kai. I roto i te keehi o te pakaru o te peera, ka kapi ki te cholesterol, e arahi ana ki te hanganga o nga kohatu cholesterol. He whanaketanga te kiripaka. Ko te Hypercholesterolemia he tohu i roto i te toto.

1. Ko te hanganga o te acetoacetyl-CoA mai e rua ngota o te acetyl-CoA ma te whakamahi i te acetoacetyltransferase thiolase.

2. Ko te hanganga o te β-hydroxy-β-methylglutaryl-CoA mai i te acetoacetyl-CoA me te tuatoru acetyl-CoA ma te whakamahi i te waihiko hydroxymethylglutaryl-CoA.

3. Ko te hanganga o te mevalonate ma te whakaheke o te HMG me te whakakorehia o te HS-KoA ma te whakamahi i te tangohanga hydroxymethylglutaryl-CoA o te NADP.

4. Ko te waikawa mevalonic te phosphorylated rua me te ATP: tae atu ki te 5-phosphomevalonate, a tae atu ki te 5-pyrophosphomevalonate.

5.5-pyrophosphomevalonate kei te phosphorylated i te 3 ngota karamu, ka hanga - 3-phospho-5-pyrophosphomevalonate.

6. Ko te whakamutunga he decarboxylated me te dephosphorylated, ka hangaia te isopentenyl pyrophosphate.

7. I muri i nga momo nekehanga angitu, ka hangaia te squalene.

8. I muri i nga huringa tauhohenga, ka hangaia te lanosterol.

9. Ka hurihia teLoosterol ki te cholesterol maeneene i roto i nga membrane o te retopona endoplasmic maeneene

Ko nga whakahiatotanga o te repe thyroid, nga hiko adrenal, me nga gonads me te honongaarahi ka whakanui ake i te ngaro a te cholesterol, me te haangai hei whakahohe i a raatau ka pakaru. Kaore i whakamahia e te cholesterol tinana te urupa i roto i te ate. Ka hurihia nga hua pirau ki te waikawa tarutaru ka tukuna ki roto i nga whekau me te papa.